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Topic Started: Jul 5 2018, 04:29 AM (3 Views)
dmt1997325


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Mechanism of action:

Amlodipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium decreases the contractile activity of arterial smooth muscle cells and results in vasodilation. The vasodilatory effects of amlodipine result in an overall decrease in blood pressure. Amlodipine is a long-acting CCB that may be used to treat mild to moderate essential hypertension and exertion-related angina (chronic stable angina). Another possible mechanism is that amlodipine inhibits vascular

smooth muscle carbonic anhydrase I activity causing cellular pH increases which may be involved in regulating intracelluar calcium influx through calcium channels.

Dosage & When it is to be taken:



Adults- PO- The usual initial dose is 5 mg once daily with a maximum dose of 10 mg once daily.


Children- 6 to 17 years- The effective dose is 2.5 mg to 5 mg once daily.



Warnings and Precautions:
Caution should be exercised in patients with history of heart failure or liver disease, any allergy, who are taking other medications, elderly, during pregnancy and breastfeeding.

It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.

Avoid alcohol consumption.

It should not be used in children less than 6 years old.

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Storage Conditions:

Store it at room temperature and in an airtight container. Protect from heat Corey Brewer Jersey , light and moisture. Keep away from reach of children.




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